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Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons.
- Source :
-
Journal of Neurophysiology . Dec2011, Vol. 106 Issue 6, p3067-3072. 6p. - Publication Year :
- 2011
-
Abstract
- Chronic compression (CCD) of the dorsal root ganglion (DRG) is a model of human radicular pain produced by intraforaminal stenosis and other disorders affecting the DRG, spinal nerve, or root. Previously, we examined electrophysiological changes in small-diameter lumbar level 3 (L3) and L4 DRG neurons treated with CCD; the present study extends these observations to medium-sized DRG neurons, which mediate additional sensory modalities, both nociceptive and non-nociceptive. Whole-cell patch-clamp recordings were obtained from medium-sized somata in the intact DRG in vitro. Compared with neurons from unoperated control animals, CCD neurons exhibited a decrease in the current threshold for action potential generation. In the CCD group, current densities of TTX-resistant and TTX-sensitive Na+current were increased, whereas the density of delayed rectifier voltage-dependent K+current was decreased. No change was observed in the transient or "A" current after CCD. We conclude that CCD in the mouse produces hyperexcitability in medium-sized DRG neurons, and the hyperexcitability is associated with an increased density of Na+current and a decreased density of delayed rectifier voltage-dependent K+current. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223077
- Volume :
- 106
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 69584376
- Full Text :
- https://doi.org/10.1152/jn.00752.2011