Evidence for a Strong Hydrogen Bond in the Catalytic Dyad of Transition-State Analogue Inhibitor Complexes of Chymotrypsin from Proton-Triton NMR Isotope Shifts.

Authors :: Westler, William M.
Frey, Perry A.
Jing Lin
Wemmer, David E.
Morimoto, Hiromi
Williams, Philip G.
Markley, John L.
Source :: Journal of the American Chemical Society. 4/24/2002, Vol. 124 Issue 16, p4196. 2p. 3 Diagrams, 1 Chart.
Publication Year :: 2002
Abstract: Investigates the strength of hydrogen bond in the catalytic dyad of transition-state analogue inhibitor complexes of chymotrypsin. List of transition state analogue inhibited complexes; Formation of low-barrier hydrogen bond; Use of tritium.

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