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Synthesis of a Novel Benzoyl Adenosine Analog Containing a 1, 4-Dioxane Sugar Analog and the Synthesis of a Corresponding Uracil Adenine Dinucleotide.
- Source :
-
Molecules . May2011, Vol. 16 Issue 5, p3985-3998. 14p. 17 Diagrams. - Publication Year :
- 2011
-
Abstract
- Adenosine analogs in which the sugar unit was replaced by a 1,4-dioxane sugar equivalent, were prepared by coupling the 1,4-dioxane sugar analog as its anomeric acetates, with N6-benzoyl protected adenine. The 1,4-dioxane system was obtained in an enantioselective synthesis from (R,R)-dimethyl tartrate. Using standard phosphorimidite methodology, the adenine analog was further reacted with a 1,4-dioxane uridine analog to give the corresponding, protected dinucleotide, set-up for further condensation into larger oligonucleotides. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADENOSINES
*DIOXANE
*ADENINE
*OLIGONUCLEOTIDES
*ACETATES
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 16
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 67792596
- Full Text :
- https://doi.org/10.3390/molecules16053985