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Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers.

Authors :
Ma. Jesús Pérez de Vega
García-López, Ma. Teresa
Zaccaro, Laura
Royo, Miriam
Albericio, Fernando
Fernández-Carvajal, Asia
Ferrer-Montiel, Antonio
González-Muñiz, Rosario
Source :
Molecules. Jul2010, Vol. 15 Issue 7, p4924-4933. 10p. 1 Diagram, 1 Chart, 1 Graph.
Publication Year :
2010

Abstract

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
15
Issue :
7
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
67676428
Full Text :
https://doi.org/10.3390/molecules15074924