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The chromosome 9 ALS and FTD locus is probably derived from a single founder

Authors :
Mok, Kin
Traynor, Bryan J.
Schymick, Jennifer
Tienari, Pentti J.
Laaksovirta, Hannu
Peuralinna, Terhi
Myllykangas, Liisa
Chiò, Adriano
Shatunov, Aleksey
Boeve, Bradley F.
Boxer, Adam L.
DeJesus-Hernandez, Mariely
Mackenzie, Ian R.
Waite, Adrian
Williams, Nigel
Morris, Huw R.
Simón-Sánchez, Javier
van Swieten, John C.
Heutink, Peter
Restagno, Gabriella
Source :
Neurobiology of Aging. Jan2012, Vol. 33 Issue 1, p209.e3-209.e8. 0p.
Publication Year :
2012

Abstract

Abstract: We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01974580
Volume :
33
Issue :
1
Database :
Academic Search Index
Journal :
Neurobiology of Aging
Publication Type :
Academic Journal
Accession number :
67321065
Full Text :
https://doi.org/10.1016/j.neurobiolaging.2011.08.005