Back to Search
Start Over
PKgraph: An R package for graphically diagnosing population pharmacokinetic models
- Source :
-
Computer Methods & Programs in Biomedicine . Dec2011, Vol. 104 Issue 3, p461-471. 11p. - Publication Year :
- 2011
-
Abstract
- Abstract: Population pharmacokinetic (PopPK) modeling has become increasing important in drug development because it handles unbalanced design, sparse data and the study of individual variation. However, the increased complexity of the model makes it more of a challenge to diagnose the fit. Graphics can play an important and unique role in PopPK model diagnostics. The software described in this paper, PKgraph, provides a graphical user interface for PopPK model diagnosis. It also provides an integrated and comprehensive platform for the analysis of pharmacokinetic data including exploratory data analysis, goodness of model fit, model validation and model comparison. Results from a variety of modeling fitting software, including NONMEM, Monolix, SAS and R, can be used. PKgraph is programmed in R, and uses the R packages lattice, ggplot2 for static graphics, and rggobi for interactive graphics. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01692607
- Volume :
- 104
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Computer Methods & Programs in Biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 67136414
- Full Text :
- https://doi.org/10.1016/j.cmpb.2011.03.016