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Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5Δ32 allele.
- Source :
-
Lancet . 5/25/2002, Vol. 359 Issue 9320, p1832. 3p. 1 Chart, 1 Graph. - Publication Year :
- 2002
-
Abstract
- Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of white people are homozygous for a non-functional CCR5 allele, containing a 32 base pair deletion (CCR5Δ32). We studied the persistence of dual-tropic HIV-1 in an individual homozygous for this deletion. Our results suggest that structural features of the HIV-1 envelope linked to CCR5 tropism could confer a selective advantage in vivo. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*VIRAL replication
*CYTOLOGICAL research
*VIRAL envelopes
Subjects
Details
- Language :
- English
- ISSN :
- 01406736
- Volume :
- 359
- Issue :
- 9320
- Database :
- Academic Search Index
- Journal :
- Lancet
- Publication Type :
- Academic Journal
- Accession number :
- 6710646
- Full Text :
- https://doi.org/10.1016/S0140-6736(02)08681-6