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Alloimmune Response Results in Expansion of Autoreactive Donor CD4+T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease.
- Source :
-
Journal of Immunology . 1/15/2011, Vol. 186 Issue 2, p856-868. 13p. - Publication Year :
- 2011
-
Abstract
- Chronic graft-versus-host disease (cGVHD) is considered an autoimmune-like disease mediated by donor CD4+ T cells, but the origin of the autoreactive T cells is still controversial. In this article, we report that the transplantation of DBA/2 donor spleen cells into thymectomized MHC-matched allogeneic BALB/c recipients induced autoimmune-like cGVHD, although not in control syngeneic DBA/2 recipients. The donor-type CD4+ T cells from the former but not the latter recipients induced autoimmune-like manifestations in secondary allogeneic BALB/c as well as syngeneic DBA/2 recipients. Transfer of donor-type CD4+ T cells from secondary DBA/2 recipients with disease into syngeneic donor-type or allogeneic host-type tertiary recipients propagated autoimmune-like manifestations in both. Furthermore, TCR spectratyping revealed that the clonal expansion of the autoreactive CD4+ T cells in cGVHD recipients was initiated by an alloimmune response. Finally, hybridoma CD4+ T clones derived from DBA/2 recipients with disease proliferated similarly in response to stimulation by syngeneic donor-type or allogeneic host-type dendritic cells. These results demonstrate that the autoimmune-like manifestations in cGVHD can be mediated by a population of donor CD4+ T cells in transplants that simultaneously recognize Ags presented by both donor and host APCs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AUTOIMMUNE diseases
*T cells
*DENDRITIC cells
*SPLEEN
*AUTOIMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 186
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 67075635
- Full Text :
- https://doi.org/10.4049/jimmunol.1002195