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β-Catenin Inhibits T Cell Activation by Selective Interference with Linker for Activation of T Cells—Phospholipase C-γ1 Phosphorylation.
- Source :
-
Journal of Immunology . 1/15/2011, Vol. 186 Issue 2, p784-790. 7p. - Publication Year :
- 2011
-
Abstract
- Despite the defined function of the β-catenin pathway in thymocytes, its functional role in peripheral T cells is poorly understood. We report that in a mouse model, β-catenin protein is constitutively degraded in peripheral T cells. Introduction of stabilized β-catenin into primary T cells inhibited proliferation and cytokine secretion after TCR stimulation and blunted effector cell differentiation. Functional and biochemical studies revealed that β-catenin selectively inhibited linker for activation of T cells phosphorylation on tyrosine 136, which was associated with defective phospholipase C-γ1 phosphorylation and calcium signaling but normal ERK activation. Our findings indicate that β-catenin negatively regulates T cell activation by a previously undescribed mechanism and suggest that conditions under which β-catenin might be inducibly stabilized in vivo would be inhibitory for T cell-based immunity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYROSINE
*T cells
*PHOSPHOLIPASE C
*PHOSPHORYLATION
*CYTOKINES
*CELL differentiation
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 186
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 67075627
- Full Text :
- https://doi.org/10.4049/jimmunol.1001562