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Identification of common mechanisms between endometriosis and ovarian cancer.
- Source :
-
Journal of Assisted Reproduction & Genetics . Oct2011, Vol. 28 Issue 10, p917-923. 7p. - Publication Year :
- 2011
-
Abstract
- Purpose: To determine common molecular markers between endometriosis and ovarian cancer. Methods: Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions ( n = 7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum ( n = 7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR. Results: Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR. Conclusions: Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10580468
- Volume :
- 28
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Assisted Reproduction & Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 67031360
- Full Text :
- https://doi.org/10.1007/s10815-011-9573-1