The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.

Authors :: Roh, Michael H.
Makarova, Olga
Chia-Jen Liu
KunYoo Shin
Seonok Lee
Laurinec, Stephanie
Goyal, Meera
Wiggins, Roger
Margolis, Ben
Source :: Journal of Cell Biology. 4/1/2002, Vol. 157 Issue 1, p161. 12p. 7 Color Photographs, 4 Black and White Photographs, 22 Diagrams, 1 Chart.
Publication Year :: 2002
Abstract: Demonstrates that the L27N domain in membrane-associated guanylate kinase proteins targets Pals1 to tight junctions. Importance of Pals1-associated tight junction (PATJ) for epithelial polarity; Colocalization of PATJ with the apical polarity determinant, Crumbs, in tight junctions; Representation of a crucial polarity gene in Drosophila.

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