Back to Search
Start Over
Prenatal Lead Exposure and Weight of 0- to 5-Year-Old Children in Mexico City.
- Source :
-
Environmental Health Perspectives . Oct2011, Vol. 119 Issue 10, p1436-1441. 6p. 3 Charts. - Publication Year :
- 2011
-
Abstract
- Background: Cumulative prenatal lead exposure, as measured by maternal bone lead burden, has been associated with smaller weight of offspring at birth and 1 month of age, but no study has examined whether this effect persists into early childhood. Objective: We investigated the association of perinatal maternal bone lead, a biomarker of cumulative prenatal lead exposure, with children's attained weight over time from birth to 5 years of age. Methods: Children were weighed at birth and at several intervals up until 60 months. Maternal tibia and patella lead were measured at 1 month postpartum using in vivo K-shell X-ray fluorescence. We used varying coefficient models with random effects to assess the association of maternal bone lead with weight trajectories of 522 boys and 477 girls born between 1994 and 2005 in Mexico City. Results: After controlling for breast-feeding duration, maternal anthropometry, and socio- demographic characteristics, a 1-SD increase in maternal patella lead (micrograms per gram) was associated with a 130.9--g decrease in weight [95% confidence interval (CI), -227.4 to -34.4 g] among females and a 13.0--g nonsignificant increase in weight among males (95% CI, -73.7 to 99.9 g) at 5 years of age. These associations were similar after controlling for concurrent blood lead levels between birth and 5 years. Conclusions: Maternal bone lead was associated with lower weight over time among female but not male children up to 5 years of age. Given that the association was evident for patellar but not tibial lead levels, and was limited to females, results need to be confirmed in other studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANALYSIS of variance
*BODY weight
*CHI-squared test
*CHILD development
*CHILDREN
*CONFIDENCE intervals
*INFANT development
*INTERVIEWING
*LEAD
*LEAD poisoning
*MATERNAL-fetal exchange
*MOTHERS
*PATELLA
*PRENATAL influences
*REGRESSION analysis
*RESEARCH funding
*SEX distribution
*STATISTICS
*T-test (Statistics)
*TIBIA
*X-ray spectroscopy
*ENVIRONMENTAL exposure
*REPEATED measures design
*DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 119
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 66648263
- Full Text :
- https://doi.org/10.1289/ehp.1003184