Two New Meroterpenes from the Mangrove Endophytic Fungus Aspergillus sp. 085241B.

Two new meroterpenes, 'acetoxydehydroaustin B' ( 1) and '1,2-dihydro-acetoxydehydroaustin B' ( 2) were isolated in the form of a mixed crystal from the mangrove endophytic fungus Aspergillus sp. 085241B. Their structures and absolute configurations were determined by extensive analysis of their spectra and X-ray diffraction data. In a preliminary bioassay, the mixed crystal did not exhibit activities against cancer cell lines of MDA-MB-435, SKBR3, HepG2, HEP3B, PC-3, and A549, as well as against α-glucosidase and tyrosinase. [ABSTRACT FROM AUTHOR]