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NUT Midline Carcinoma Mimicking Tonsillitis in an Eight-Year-Old Girl.
- Source :
-
Annals of Otology, Rhinology & Laryngology . Aug2011, Vol. 120 Issue 8, p546-549. 4p. 7 Black and White Photographs. - Publication Year :
- 2011
-
Abstract
- We review a unique case of NUT midline carcinoma that presented in a young girl with an initial diagnosis of tonsillar abscess. We stress the importance of assaying poorly differentiated carcinomas in young patients for the t(15;19) translocation. Our patient presented with tonsillar enlargement and cervical lymphadenopathy mimicking acute tonsillitis. The clinical suspicion for malignancy arose after an aspirate from the tonsil did not yield any pus, and biopsy of a cervical lymph node demonstrated undifferentiated carcinoma. Further analysis by fluorescence in situ hybridization was positive for rearrangements in both BRD4 and NUT genes consistent with NUT carcinoma. In addition, fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed a very high standard uptake value in both the primary tumor and meta-static foci, suggesting that FDG-PET could be a useful tool in the staging and follow-up of NUT midline carcinoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LYMPHATIC disease diagnosis
*TONSILLITIS
*BIOPSY
*CANCER chemotherapy
*DEOXY sugars
*DIFFERENTIAL diagnosis
*DIAGNOSTIC errors
*SURGICAL excision
*IMMUNOHISTOCHEMISTRY
*LYMPH node surgery
*ONCOGENES
*HEALTH outcome assessment
*RADIOPHARMACEUTICALS
*POSITRON emission tomography
*SQUAMOUS cell carcinoma
*FLUORESCENCE in situ hybridization
*TREATMENT effectiveness
*RESPIRATORY aspiration
*CHILDREN
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00034894
- Volume :
- 120
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Annals of Otology, Rhinology & Laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 65353194
- Full Text :
- https://doi.org/10.1177/000348941112000810