Dystrophin-deficient muscular dystrophy in an Alaskan malamute.

Authors :: Ito, D.
Kitagawa, M.
Jeffery, N.
Okada, M.
Yoshida, M.
Kobayashi, M.
Nakamura, A.
Watari, T.
Source :: Veterinary Record: Journal of the British Veterinary Association. 7/30/2011, Vol. 169 Issue 5, following p127-127. 4p. 1 Color Photograph, 1 Black and White Photograph, 1 Chart.
Publication Year :: 2011
Abstract: The article presents information on a study which examined dystrophin-deficient muscular dystrophy (MD) in an Alaskan malamute, which showed the characteristic clinical signs, elevated serum muscle enzymes and abnormal electromyographical (EMG) findings at four months of age. It notes that full-length dystrophin as absent in the Alaskan malamute, as revealed by western blotting. It also discusses the results of serological tests, magnetic resonance imaging (MRI), and haematoxylin and eosin-stained muscle biopsy specimens.