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Implication of HLA-DMA Alleles in Corsican IDDM.
- Source :
-
Disease Markers . 1998, Vol. 14 Issue 3, p135. 7p. - Publication Year :
- 1998
-
Abstract
- The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETIC polymorphisms
*HLA histocompatibility antigens
Subjects
Details
- Language :
- English
- ISSN :
- 02780240
- Volume :
- 14
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Disease Markers
- Publication Type :
- Academic Journal
- Accession number :
- 6375219
- Full Text :
- https://doi.org/10.1155/1998/705857