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Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1–42 oligomer injection
- Source :
-
Neurobiology of Learning & Memory . Sep2011, Vol. 96 Issue 2, p306-314. 9p. - Publication Year :
- 2011
-
Abstract
- Abstract: Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer’s disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50mg/kg/day, 5days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10747427
- Volume :
- 96
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Learning & Memory
- Publication Type :
- Academic Journal
- Accession number :
- 63555168
- Full Text :
- https://doi.org/10.1016/j.nlm.2011.06.004