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Protein Nanoarrays Generated By Dip-Pen nanolithography.
- Source :
-
Science . 3/1/2002, Vol. 295 Issue 5560, p1702-1705. 4p. 3 Diagrams, 1 Graph. - Publication Year :
- 2002
-
Abstract
- Dip-pen nanolithography was used to construct arrays of proteins with 100- to 350-nanometer features. These nanoarrays exhibit almost no detectable nonspecific binding of proteins to their passivated portions even in complex mixtures of proteins, and therefore provide the opportunity to study a variety of surface-mediated biological recognition processes. For example, reactions involving the protein features and antigens in complex solutions can be screened easily by atomic force microscopy. As further proof-of-concept, these arrays were used to study cellular adhesion at the submicrometer scale. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEINS
*LITHOGRAPHY
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 295
- Issue :
- 5560
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 6343540
- Full Text :
- https://doi.org/10.1126/science.1067172