A facile one-pot synthesis of 1,3,4-thiadiazine-5-yl-pyran-2-one derivatives via a multicomponent reaction.

A facile synthesis of 1,3,4-thiadiazine-5-yl-pyran-2-one derivatives is achieved via a three-component reaction involving 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiocarbohydrazide with various carbonyl compounds in one-pot under stirring. The main advantage of this procedure is the short reaction time, high yields, simple workup, and purification of products by non-chromatographic methods, i.e. by simple recrystallization from ethanol. The structures of newly prepared compounds have been established by elemental analysis and spectral data. [image omitted] [ABSTRACT FROM AUTHOR]