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Duration of anti-tubercular treatment in tuberculous meningitis: Challenges and opportunity.
- Source :
-
Neurology India . Oct2010, Vol. 58 Issue 5, p723-726. 4p. 1 Chart. - Publication Year :
- 2010
-
Abstract
- Background: The duration of anti-tuberculous therapy in tuberculous meningitis is controversial. There is variation in recommendations by different societies and expert groups on this issue. Objective: To determine the strength of evidence for short-term therapy in tuberculous meningitis through review of literature and critical appraisal. Materials and Methods: Cochrane CENTRAL (Issue 4, 2010), TRIP database, and PubMed (from 1966 to present) were searched for relevant papers with keywords 'meningeal tuberculosis' and tuberculous meningitis' combined with 'chemotherapy'. A critical appraisal of a systematic review was done using standard criteria. Results: A total of 10 relevant papers were identified. All papers were included in a systematic review. The systematic review did not specify study design of studies to be included, had only case series but no randomised controlled trial, and unclear definition of endpoints. Conclusions: The evidence base for short-term therapy for tuberculous meningitis is weak. There is a need to conduct a randomised controlled trial with non-inferiority hypothesis of adequate sample size with well-defined end points and adequate follow-up. This is a challenge as well as opportunity for Indian neurologists. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00283886
- Volume :
- 58
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Neurology India
- Publication Type :
- Academic Journal
- Accession number :
- 63157673
- Full Text :
- https://doi.org/10.4103/0028-3886.72182