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A Revised Mechanism for the Inactivation of Bovine Liver Enoyl-CoA Hydratase...
- Source :
-
Biochemistry . 2/12/2002, Vol. 41 Issue 6, p1843. 10p. 3 Diagrams, 7 Graphs. - Publication Year :
- 2002
-
Abstract
- Reports on the compound (methylenecyclopropyl)formyl-coenzymeA (MCPF-CoA) as a potent active site-directed inactivator of bovine liver enoyl-CoA hydratase (ECH). Mechanism of inactivation; Role of the residue C114A mutant of bovine liver ECH in the catalytic mechanism of the enzyme; Proposed modified mechanism of inactivation involving Glu115 and Glu135, suggesting that MCPF-CoA may be a mechanism-based inhibitor for bovine liver ECH.
- Subjects :
- *COENZYMES
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 41
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 6314645
- Full Text :
- https://doi.org/10.1021/bi0119363