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Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2011, Vol. 21 Issue 15, p4507-4511. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: The synthesis and SAR of a series of novel pyrazolo-quinazolines as potent and selective MPS1 inhibitors are reported. We describe the optimization of the initial hit, identified by screening the internal library collection, into an orally available, potent and selective MPS1 inhibitor. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 21
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 62843576
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.05.122