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Histiocytic Sarcoma of the Spleen Associated with Hypoalbuminemia, Hypo γ-globulinemia and Thrombocytopenia as a Possibly Unique Clinical Entity--Report of Three Cases.
- Source :
-
Leukemia & Lymphoma . Sep98, Vol. 31 Issue 1/2, p217. 8p. 2 Black and White Photographs, 3 Charts, 1 Graph. - Publication Year :
- 1998
-
Abstract
- We report three patients with histiocytic sarcoma of the spleen associated with severe hypoalbuminemia, hypo γ-globulinemia and thrombocytopenia. After the clinical diagnosis of splenic tumor of unknown origin was made, all three patients underwent splenectomy. The histiocytic origin of the tumor was confirmed histopathologically and immunohistochemically using a panel of antibodies. in contrast to malignant histiocytosis (MH), which typically reveals severe generalized clinical manifestations and a rapidly fatal course caused by the disseminated proliferation of neoplastic histiocytes, these patients were asymptomatic or showed only mild clinical symptoms for a long period of time until the recurrence was detected by which time the tumor cells had already spread to other organs. All three cases were characteristically associated with hypoalbuminemia, hypo γ-globulinemia and thrombocytopenia, which returned to normal after splenectomy. Splenic histiocytic sarcoma with the features described here may represent a unique clinical entity, distinct from MH. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RETICULUM cell sarcoma
*SPLEEN cancer
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 31
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 6280083
- Full Text :
- https://doi.org/10.3109/10428199809057601