Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome.

This article discusses a study which examined the prevalence of Klinefelter's syndrome in patients with systemic lupus erythematosus (SLE). The study used fluorescence in situ hybridization (FISH) and karyotyping in transformed B cell lines in the investigating the association between the two disorders. It showed an increase in the frequency of Klinefelter's syndrome in men with SLE.