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Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis
- Source :
-
Fertility & Sterility . Jul2011, Vol. 96 Issue 1, p113-117. 5p. - Publication Year :
- 2011
-
Abstract
- Objective: To examine the effects of interleukin (IL)-17F on the secretion of IL-8 and the gene expression of cyclooxygenase 2 (COX2) in endometriotic stromal cells. Design: In vitro experimental study using human samples. Setting: University hospital. Patient(s): Endometriotic tissues were obtained from women with ovarian endometriomas undergoing laparoscopic surgery. Intervention(s): Endometriotic stromal cells (ESCs) were cultured with IL-17F. Main Outcome Measure(s): Concentrations of IL-8 were measured by a specific ELISA, and messenger RNA levels of IL-8 and COX2 were measured by real-time reverse transcription–polymerase chain reaction (PCR). Result(s): IL-17F increased the secretion of IL-8 from ESCs, and the effect was inhibited by antibodies for IL-17 receptor A and IL-17 receptor C. Tumor necrosis factor α (TNF-α) synergistically enhanced IL-17F-induced increase in IL-8 secretion from ESCs. The IL-17F increased the gene expression of IL-8 and COX2 in ESCs. Conclusion(s): These findings suggest that IL-17F may stimulate the development of endometriosis by up-regulation of IL-8 and COX2. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 96
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 62394699
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2011.04.060