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Clinical significance of serum Dkk-3 in patients with gynecological cancer.
- Source :
-
Journal of Obstetrics & Gynaecology Research . Aug2010, Vol. 36 Issue 4, p769-773. 5p. 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Aim: The expression of Dkk-3, as a number of the Dkk family was different in different cancer. Because Dkk-3 encodes a secreted protein, we investigated whether the Dkk-3 protein is secreted into the sera of patients with gynecological cancer. Material & Methods: The levels of Dkk-3 protein were assessed by enzyme-linked immunosorbent assay in the sera of 104 patients with gynecological cancer: 36 with ovarian, 40 with cervical and 28 with endometrial cancers. Results: The serum levels of Dkk-3 protein in patients with ovarian cancer [25.54 (7.99) pg/mL] was lower than in normal individuals [42.08 (14.89) pg/mL] ( P = 0.000). But serum levels of Dkk-3 protein in patients with cervical [166.39 (300.68) pg/mL] ( P = 0.013) and endometrial cancers [73.64 (23.36) pg/mL] ( P = 0.000) were higher than in normal individuals. The serum levels of Dkk-3 protein were associated with clinical stage in patients with cervical and endometrial cancers. In patients with ovarian cancer, the serum levels of Dkk-3 protein were associated with lymphatic metastasis. In patients with cervical cancer, the serum levels of Dkk-3 protein were associated with tumor diameters. Conclusion: Dkk-3 protein detection using enzyme-linked immunosorbent assay as molecular markers can contribute to detection and diagnosis of gynecological cancer, especially for ovarian cancer and endometrial cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEIN metabolism
*DIAGNOSIS of female reproductive organ tumors
*ACADEMIC medical centers
*ANALYSIS of variance
*ELECTROPHYSIOLOGY
*ENZYME-linked immunosorbent assay
*METABOLISM
*OVARIAN tumors
*RESEARCH funding
*T-test (Statistics)
*TUMOR markers
*CASE-control method
*RECEIVER operating characteristic curves
Subjects
Details
- Language :
- English
- ISSN :
- 13418076
- Volume :
- 36
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Obstetrics & Gynaecology Research
- Publication Type :
- Academic Journal
- Accession number :
- 62122282
- Full Text :
- https://doi.org/10.1111/j.1447-0756.2010.01234.x