Cerebral Thrombosis And Microcirculation Of The Rat During The Oestrous Cycle And After Ovariectomy.

SUMMARY 1. The effects of oestrogen on thrombogenesis and the cerebral microcirculation of the female rat were studied during the oestrous cycle and after ovariectomy. 2. Serum levels of oestradiol (E2) and plasma concentrations of nitric oxide (NO) metabolites were significantly greater at prooestrus than at dioestrus. Blood vessel diameter, mean red cell velocity, wall shear rate and blood flow at pro-oestrus were significantly higher than at dioestrus. Thrombotic tendency, assessed using a He–Ne laser-induced thrombosis model, was significantly decreased at pro-oestrus compared with dioestrus. [ABSTRACT FROM AUTHOR]