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Sustained transdermal release of diltiazem hydrochloride through electron beam irradiated different PVA hydrogel membranes
- Source :
-
Nuclear Instruments & Methods in Physics Research Section B . Aug2011, Vol. 269 Issue 16, p1822-1828. 7p. - Publication Year :
- 2011
-
Abstract
- Abstract: Extremely fast release of diltiazem hydrochloride (water soluble, anti anginal drug used to treat chest pain) together with its faster erosion has been the primary problem in conventional oral therapy. It has been addressed in this paper by encapsulating the drug in electron beam irradiated various poly (vinyl alcohol) hydrogel membranes and delivering it through transdermal route. Results show excellent control over the release of diltiazem hydrochloride through these membranes subject to their physico-mechanicals. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0168583X
- Volume :
- 269
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Nuclear Instruments & Methods in Physics Research Section B
- Publication Type :
- Academic Journal
- Accession number :
- 61485306
- Full Text :
- https://doi.org/10.1016/j.nimb.2011.05.011