Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus...

Authors :: Shiver, John W.
Ton-Ming Fu
Ling Chen
Casimiro, Danilo R.
Davies, Mary-Ellen
Evans, Robert K.
Zhi-Qiang Zhang
Simon, Adam J.
Trigona, Wendy L.
Dubey, Sheri A.
Lingyi Huang
Harris, Virginia A.
Long, Romnie S.
Xiaoping Liang
Handt, Larry
Schleif, William A.
Zhu, Lan
Freed, Daniel C.
Persaud, Natasha V.
Source :: Nature. 1/17/2002, Vol. 415 Issue 6869, p331-335. 5p. 1 Chart, 25 Graphs.
Publication Year :: 2002
Abstract: Shows that the most effective responses were elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector. Assessment of several vaccine vector delivery systems; Outcome of immunization and viral challenge studies conducted in rhesus macaque monkeys.

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