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Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2011, Vol. 21 Issue 13, p4027-4031. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: The design and synthesis of a new series of high efficacy β2 -agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2 -agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2-adrenoceptor crystal structure, other biophysical data and modeling studies. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 21
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 61255753
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.04.135