Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells.

Authors :: Kusaba, Hitoshi
Nakayama, Masaharu
Harada, Taishi
Nomoto, Minoru
Kohno, Kimitoshi
Kuwano, Michihiko
Wada, Morimasa
Source :: European Journal of Biochemistry. Jun99 Part 2, Vol. 262 Issue 3, p924. 9p. 13 Diagrams.
Publication Year :: 1999
Abstract: Investigates the relation between methylation status of CpG sites in the multidrug resistance 1 gene (MDR1) promoter region and transcriptional activation of MDR1. Examination of P-glycoprotein-overexpressing, multidrug resistant KB/VJ300 and KB-C1 cells; Activation of MDR1 i KB/VJ300 cells; Determination of the methylation status.

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