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Design and synthesis of protein kinase Cα activators based on ‘out of pocket’ interactions
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2011, Vol. 21 Issue 12, p3587-3590. 4p. - Publication Year :
- 2011
-
Abstract
- Abstract: Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 21
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 61173406
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.04.108