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The response to TLR ligation of human CD16+CD14− monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus
- Source :
-
Molecular Immunology . Jul2011, Vol. 48 Issue 12/13, p1505-1511. 7p. - Publication Year :
- 2011
-
Abstract
- Abstract: Little is known about the frequency and function of CD16+CD14− monocytes from chronic HCV patients. We observed that the absolute numbers and ratio of CD16+CD14− to CD14+CD16− monocytes were similar between chronic HCV patients and healthy individuals. Functionally, we found that CD16+CD14− monocytes are more responsive to TLR8-ligation and only weakly responsive to LPS stimulation in producing TNF as compared to CD14+CD16− monocytes. We found no overt impairment of the function of CD16+CD14− monocytes from patients, except for an augmented induction of MIP-1β-producing CD16+CD14− monocytes upon TLR4-ligation. However, the increased frequency of MIP-1β-producing CD16+CD14− monocytes was not associated with viral load, ALT or fibrosis level. Our findings indicate that, different from other infectious diseases, the frequency and function of CD16+CD14− monocytes are only minimally altered as a consequence of the persistent state of HCV infections, and our findings therefore do not suggest a role for CD16+CD14− monocytes in HCV pathogenesis. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01615890
- Volume :
- 48
- Issue :
- 12/13
- Database :
- Academic Search Index
- Journal :
- Molecular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 61172107
- Full Text :
- https://doi.org/10.1016/j.molimm.2011.04.008