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Evaluation of light/dark cycle in anxiety- and depressive-like behaviors after regular treatment with methylphenidate hydrochloride in rats of different ages.
- Source :
-
Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria . mar2011, Vol. 33 Issue 1, p55-58. 4p. - Publication Year :
- 2011
-
Abstract
- Objective: Methylphenidate hydrochloride is the most widely used medication for treatment and management of attention-deficit hyperactivity disorder. However, the chronic effects of methylphenidate hydrochloride on anxiety- and depressive-like rat behaviors remain poorly investigated. In this context, the present study evaluated the effects of treatment with methylphenidate hydrochloride on anxiety-and depressive-like behaviors using young and adult rats during the light and the dark cycle. Method: Male Wistar rats (25 or 60 days old) received a once-daily (in either the light or dark cycle) methylphenidate hydrochloride (2mg/kg) or saline intraperitoneal injection for 28 days. We performed elevated plus maze and forced swimming test two hours after the last injection. Results: The light/dark cycle was a significant factor in the anxiety-like behaviors; however, no significant interaction between all three factors (cycle, age and methylphenidate hydrochloride) was found. Nevertheless, we observed a nominally significant interaction between the light/dark cycle and age in the forced swimming test. Conclusion: Our results have shown that age and the light/dark cycle are more significant modulators of anxiety- and depressive-like behaviors than methylphenidate hydrochloride treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15164446
- Volume :
- 33
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria
- Publication Type :
- Academic Journal
- Accession number :
- 61152755