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Synthesis, characterization and cytotoxic effect of ring-substituted and ansa-bridged vanadocene complexes
- Source :
-
Inorganica Chimica Acta . Jul2011, Vol. 373 Issue 1, p1-7. 7p. - Publication Year :
- 2011
-
Abstract
- Abstract: The cytotoxic effect of vanadocene dichloride (Cp2VCl2, 1) and its ring-substituted, (η5-C5H4Me)2VCl2 (2), (η5-C5Me5)2VCl2 (3), (η5-C5H4R)2VCl2 (4: R=MeOCH2CH2–, 5: R=2-MeOC6H4CH2–, 6: R=4-MeOC6H4CH2–) and ansa-bridged analogs Me2C(η5-C5H4)2VCl2 (7) and Me4C2(η5-C5H4)2VCl2 (8) was investigated. Synthesis of two new methoxy-functionalized compounds (4 and 5) is described. They were characterized by spectroscopic methods and X-ray diffraction analysis. The cytotoxicity studies were performed with leukemic cells MOLT-4. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00201693
- Volume :
- 373
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Inorganica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 60926412
- Full Text :
- https://doi.org/10.1016/j.ica.2011.03.034