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Small dense LDL cholesterol is a robust therapeutic marker of statin treatment in patients with acute coronary syndrome and metabolic syndrome
- Source :
-
Clinica Chimica Acta . Jul2011, Vol. 412 Issue 15/16, p1423-1427. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: Background: Small dense low-density lipoprotein (sd-LDL) is an atherogenic LDL subfraction and often increased in metabolic syndrome (MetS). This study aimed to determine whether sd-LDL cholesterol (sd-LDL-C) is a therapeutic marker of statin treatment in patients with acute coronary syndrome (ACS) and MetS. Methods: We examined 71 patients with ACS and 50 non-ACS subjects with normal coronary arteries (controls). The patients with ACS were treated with life-style modifications (n=36) or those plus 20mg atorvastatin daily (n=35) for 6months. We measured sd-LDL-C by a novel detergent-based homogenous assay and calculated buoyant LDL-C (b-LDL-C). Results: The patients with ACS had higher sd-LDL-C than did the controls (30±14 vs. 22±8mg/dl, p<0.001). Furthermore, sd-LDL-C was higher in the patients with ACS and MetS (n=31) than in those without MetS (n=40) (35±17 vs. 27±11mg/dl, p<0.05). Atorvastatin reduced LDL-C and sd-LDL-C by 31% (102±23 to 70±28mg/dl, p<0.0001) and 24% (29±15 to 22±13mg/dl, p<0.01). The reduction in sd-LDL-C by atorvastatin was 5.5-fold greater in the patients with ACS and MetS than in those without MetS (p<0.001). Contrary, that in b-LDL-C was similar between the groups. Conclusions: sd-LDL-C is a superior therapeutic marker of statin treatment in patients with ACS and MetS. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 412
- Issue :
- 15/16
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 60925850
- Full Text :
- https://doi.org/10.1016/j.cca.2011.04.021