Back to Search Start Over

No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders.

Authors :
Kindler, Jochen
Bailer, Ursula
de Zwaan, Martina
Fuchs, Karoline
Leisch, Friedrich
Grün, Bettina
Strnad, Alexandra
Stojanovic, Mirjana
Windisch, Julia
Lennkh-Wolfsberg, Claudia
El-Giamal, Nadja
Sieghart, Werner
Kasper, Siegfried
Aschauer, Harald
Source :
Nordic Journal of Psychiatry. Jun2011, Vol. 65 Issue 3, p203-207. 5p. 2 Charts.
Publication Year :
2011

Abstract

Background: Genetic factors likely contribute to the biological vulnerability of eating disorders. Aims: Case--control association study on one neuropeptide Y gene (Leu7Pro) polymorphism and three ghrelin gene (Arg51Gln, Leu72Met and Gln90Leu) polymorphisms. Methods: 114 eating disorder patients (46 with anorexia nervosa, 30 with bulimia nervosa, 38 with binge eating disorder) and 164 healthy controls were genotyped. Results: No differences were detected between patients and controls for any of the four polymorphisms in allele frequency and genotype distribution ( P > 0.05). Allele frequencies and genotypes had no significant influence on body mass index ( P > 0.05) in eating disorder patients. Conclusion: Positive findings of former case--control studies of associations between ghrelin gene polymorphisms and eating disorders could not be replicated. Neuropeptide Y gene polymorphisms have not been investigated in eating disorders before. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08039488
Volume :
65
Issue :
3
Database :
Academic Search Index
Journal :
Nordic Journal of Psychiatry
Publication Type :
Academic Journal
Accession number :
60571872
Full Text :
https://doi.org/10.3109/08039488.2010.525258