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Effect of Streptomyces 23-2B metabolites on hepatic lipid peroxidation and some antioxidant parameters in Wister rats.
- Source :
-
World Journal of Microbiology & Biotechnology . Dec2010, Vol. 26 Issue 12, p2185-2191. 7p. - Publication Year :
- 2010
-
Abstract
- Streptomyces 23-2B is one of actinomycetes associated with marine clam Donax trunculus and has potential source of bioactive metabolites, which possesses a broad spectrum antibiotic and anticancer activities. This study aims to evaluate the effect of Streptomyces 23-2B metabolites on hepatic lipid peroxidation (LPO), reduced glutathione (GSH) levels, as well as serum uric acid, total cholesterol (TC), triglyceride (TG), nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) levels of rat. Animals were divided into four groups: the control group, which received 0.1 ml of 10% Tween-80 by intraperitoneally injection, and the other three experimental groups, which received 10% Tween 80 solution of Streptomyces 23-2B metabolites in doses of 0.5, 5 and 50 mg/kg body weight at an interval 2 days for 2 weeks. LPO levels showed significant decrease with the lowest doses. The effect at a dose of 50 mg/kg of Streptomyces 23-2B metabolites on TG was more pronounced than the other two doses (0.5 and 5 mg/kg body weight). Hypocholesterolemia was recorded in the treated rats with 0.5 and 5 mg/kg of Streptomyces 23-2B. However, the highest dose enhanced the elevation of serum TNF-α and NO levels. Thus, the present study reveals that Streptomyces 23-2B metabolite is a newly discovered biomaterial from microorganisms. The novel substance showed inhibitory activity against LPO in rat liver homogenate and improving the immune response by releasing TNF-α and NO in serum. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09593993
- Volume :
- 26
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- World Journal of Microbiology & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 60262332
- Full Text :
- https://doi.org/10.1007/s11274-010-0403-x