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Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice
- Source :
-
Fitoterapia . Jun2011, Vol. 82 Issue 4, p620-625. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: Chelerythrine (CHE), a quaternary benzo[c]phenanthridine alkaloid, which is an agent in traditional Chinese medicine exhibits a wide spectrum of pharmacological effects. In this study, we examined the anti-inflammatory activities and mechanism of CHE in vivo and in vitro, respectively. Further, in the analgesic test, CHE also showed pronounced inhibition of the acetic acid-induced writhing response. These results clearly suggested that CHE is a bioactive agent which has a significant anti-inflammatory action, which may be relevant to the inhibition of the release/production of exudates and prostaglandin E2 mediated through cyclooxygenase-2 regulation. [Copyright &y& Elsevier]
- Subjects :
- *PAIN
*PREVENTIVE medicine
*MEDICINAL plants
*ALTERNATIVE medicine
*ANALYSIS of variance
*ANIMAL experimentation
*ANTI-inflammatory agents
*BIOLOGICAL assay
*BIOLOGICAL models
*BIOPHYSICS
*DOSE-effect relationship in pharmacology
*MACROPHAGES
*MATHEMATICS
*RESEARCH methodology
*MICE
*PROSTAGLANDINS
*RESEARCH funding
*STATISTICS
*WESTERN immunoblotting
*PLANT extracts
*DATA analysis
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 82
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 60158141
- Full Text :
- https://doi.org/10.1016/j.fitote.2011.01.020