Ruthenium-catalyzed asymmetric transfer hydrogenation of ketones in ethanol

Authors :: Lundberg, Helena
Adolfsson, Hans
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2011, Vol. 52 Issue 21, p2754-2758. 5p.
Publication Year :: 2011
Abstract: Abstract: A ruthenium catalyst formed in situ by combining [Ru(p-cymene)Cl2]2 and an amino acid hydroxy-amide was found to catalyze efficiently the asymmetric reduction of aryl alkyl ketones under transfer hydrogenation conditions using ethanol as the hydrogen donor. The secondary alcohol products were obtained in moderate to good yields and with good to excellent enantioselectivity (up to 97% ee). [Copyright &y& Elsevier]

Subjects :: *RUTHENIUM
*METAL catalysts
*ASYMMETRY (Chemistry)
*HYDROGENATION
*KETONES
*ETHANOL
*CHEMICAL reduction
*ENANTIOSELECTIVE catalysis

Language :: English
ISSN :: 00404039
Volume :: 52
Issue :: 21
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 60157814
Full Text :: https://doi.org/10.1016/j.tetlet.2011.03.098