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SUMmOning Daxx-Mediated Repression

Authors :
Mukhopadhyay, Debaditya
Matunis, MichaelĀ J.
Source :
Molecular Cell. Apr2011, Vol. 42 Issue 1, p4-5. 2p.
Publication Year :
2011

Abstract

An intimate relationship exists between the transcriptional coregulator Daxx, SUMO, and PML nuclear bodies. In this issue, provide structural insights into how phosphorylation of Daxx increases its affinity toward SUMOs and functional insights into how enhanced SUMO binding affects Daxx-PML interactions, PML nuclear body localization, and Daxx-mediated repression of genes encoding for antiapoptotic factors. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
10972765
Volume :
42
Issue :
1
Database :
Academic Search Index
Journal :
Molecular Cell
Publication Type :
Academic Journal
Accession number :
59928412
Full Text :
https://doi.org/10.1016/j.molcel.2011.03.008