Back to Search
Start Over
Salivary biomarkers of periodontal disease in response to treatment.
- Source :
-
Journal of Clinical Periodontology . May2011, Vol. 38 Issue 5, p434-441. 8p. 2 Charts, 3 Graphs. - Publication Year :
- 2011
-
Abstract
- Background: Salivary biomarkers of periodontitis were assessed longitudinally to determine response to therapy. Methods: A 6-month case-controlled study of adults with chronic periodontitis was performed, with 33 participants receiving oral hygiene instructions (OHI) alone and 35 with scaling and root planing (SRP) combined with OHI. Saliva samples collected at week 0, 16 and 28 were analysed for interleukin (IL)-1β, IL-8, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase-8 (MMP-8), osteoprotegerin (OPG), and tumour necrosis factor-α (TNF)-α. Clinical measures of periodontal disease were recorded at each visit. Results: All parameters of periodontal health improved significantly in both groups by week 16 (p<0.0001) with the SRP group demonstrating greater benefit at week 16 and 28. Baseline OPG and TNF-α levels changed significantly at both follow-up visits (p<0.03), regardless of treatment group. IL-1β and MMP-8 levels decreased significantly from baseline (p<0.04) in the SRP group only. OPG, MMP-8, and MIP-1α were significantly reduced in responders compared with non-responders (p = 0.04, 0.01, 0.05, respectively). In receiver-operating characteristic analyses, MMP-8 produced the highest area under the curve (≥0.7; p = 0.01). Conclusion: Salivary levels of IL-1β, MMP-8, OPG, and MIP-1α reflected disease severity and response to therapy suggesting their potential utility for monitoring periodontal disease status. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PERIODONTAL disease treatment
*PROTEIN analysis
*ANALYSIS of covariance
*BIOMARKERS
*CHI-squared test
*CHRONIC diseases
*COMPUTER software
*STATISTICAL correlation
*DENTAL scaling
*FISHER exact test
*INTERLEUKINS
*LONGITUDINAL method
*PERIODONTAL disease
*PERIODONTITIS
*SALIVA
*T-test (Statistics)
*TOOTH care & hygiene
*TOOTH root planing
*TUMOR necrosis factors
*SAMPLE size (Statistics)
*DATA analysis
*STATISTICAL significance
*CASE-control method
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 38
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 59909108
- Full Text :
- https://doi.org/10.1111/j.1600-051X.2011.01706.x