Quantitative EEG amplitude across REM sleep periods in depression: preliminary report.

Discusses significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture in patients with major depressive disorder (MDD). REM latency longest in in men with MDD; Decline of slower frequencies across REM periods, with a significant REM period effect for delta, theta and alpha amplitude; Systematic temporal changes in electroencephalography over successive REM sleep periods.