Online Liquid Chromatography–Tandem Mass Spectrometry Cyanide Determination in Blood.

The article focuses on a study which developed a method using online extraction coupled to liquid chromatography-tandem mass spectrometry (LC-MS-MS) to determine cyanide (CN) in blood. The method involved the use of cyanide isotope 13C15N as internal standard (IS) for quantification in MS-MS, and derivatization step with naphtalene-2,3-dicarboxyaldehyde (NDA) and taurine. The study showed that the method is suitable for CN identification in blood and in forensic toxicology.