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Genetic variation of vascular endothelial growth factor pathway does not correlate with the severity of retinopathy of prematurity.
- Source :
-
Journal of Perinatology . Apr2011, Vol. 31 Issue 4, p246-250. 5p. 4 Charts. - Publication Year :
- 2011
-
Abstract
- Objective:The aim of this study was to assess the genetic effects of the vascular endothelial growth factor (VEGF) pathway on retinopathy of prematurity (ROP).Study Design:A prospective study from a tertiary center that enrolled 204 Japanese infants (<35 weeks of gestational age (GA)) having no anomalies. ROP developed in 127, but not in 77 infants. The relative severity was defined as non-severe, moderate and severe ROP for GA, based on the staging criteria. VEGF (g.−634G>C, g.+13553C>T) and VEGF-receptor (KDR g.+4422(AC)11 to 14, Flt-1 c.+6724(TG)13 to 23) gene polymorphisms and clinical variables were assessed by uni/multivariate analyses.Result:The frequency of polymorphisms did not differ between ROP and non-ROP patients. The TT genotype of g.+13553 showed a higher odds ratio for non-severe ROP than CC genotype (P=0.006). Multivariate analyses indicated that low birth weight, blood transfusion and respiratory distress syndrome, but not polymorphisms, were the risk factors of advanced ROP (stage 3).Conclusion:A genotype of the VEGF pathway weakly affects the severity of ROP compared with other clinical factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACADEMIC medical centers
*APGAR score
*CHI-squared test
*COMPUTER software
*FISHER exact test
*GENES
*GENETIC polymorphisms
*GROWTH factors
*LONGITUDINAL method
*GENETIC mutation
*RESEARCH funding
*RETROLENTAL fibroplasia
*STATISTICS
*LOGISTIC regression analysis
*DATA analysis
*MULTIPLE regression analysis
*SEVERITY of illness index
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 07438346
- Volume :
- 31
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 59657251
- Full Text :
- https://doi.org/10.1038/jp.2010.111