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β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 12/14/2010, Vol. 107 Issue 50, p21564-21569. 6p. 3 Color Photographs, 2 Graphs. - Publication Year :
- 2010
-
Abstract
- The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mclr) and its antagonist Agouti, but the genetic and developmental mechanisms that modify this interaction to obtain different coat color in distinct environments are poorly understood. Here, the role of Wnt/β-catenin signaling in the regulation of pigment-iype switching was studied. Loss and gain of function of β-catenin in the dermal papilla (DP) of the hair follicle results in yellow and black animals, respectively. β-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regulator of Agouti activity. In addition, β-catenin activity in the DP regulates melanocyte activity by a mechanism that is independent of both Agouti and Corin. The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive to changes in β-catenin activity in the DP that do not alter pelage structure. As a result, the signals that specify two biologically distinct quantitative traits are partially uncoupled despite their common regulation by the β-catenin pathway in the same cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MARINE service
*HAIR follicles
*EPITHELIUM
*PIGMENTS
*PAINT materials
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 107
- Issue :
- 50
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 59617768
- Full Text :
- https://doi.org/10.1073/pnas.1007326107