Applications of geometric series in pharmacokinetics.

Study of time course of a drug and its metabolites in the body after administration by any route is referred to as pharmacokinetics. Since response to any drug is a function of concentration of that drug in biophase, the aim of pharmacokinetics has been to determine what dose and dosing schedule are sufficient to elicit and maintain a desired clinical response. Pharmacokinetics mainly involves applications of calculus to derive different parameters and equations. Most of the pharmacy, medical, veterinary, and/or dental students, being unacquainted with calculus, fail to comprehend the basic concepts of pharmacokinetics. Therefore, an attempt has been made to derive some basic information regarding drug decline and drug accumulation with the help of algebraic concepts using geometric series for deriving and explaining the kinetic parameters. The article has been supported with some numerical examples for better understanding of the concept. [ABSTRACT FROM AUTHOR]