The Effects of Amlodipine on the Biochemical and Histopathological Changes in the Rabbit Ileum Subjected to Ischemia-Reperfusion.

Objective: The aim of this study was to determine the potential, protective eff ects of amlodipine in an experimental, ischemia- eperfusion (I/R) model in the rabbit small intestine. Materials and Methods: The rabbits were divided into four groups: sham-operated, mlodipine (10 mg/kg) + sham-operated, I/R, and I/R + amlodipine (10 mg/kg) groups. An intestinal I/R model was applied to the rabbits. he superior mesenteric artery was occluded for 1 h with an atraumatic vascular clamp and then was reperfused for 2 h. Animals in the mlodipine and I/R + amlodipine groups received the amlodipine by oral gavage. At the end of the 2-h-reperfusion period, the animals were sacrifi ced. Results: Pretreatment with amlodipine signifi cantly increased SOD activity and GSH levels to values close to those found in the serum from the I/R group. Rabbits in the I/R group showed high levels of serum MDA. Amlodipine pretreatment signifi cantly reduced the serum MDA levels compared to the I/R group, although the MDA levels in the I/R + amlodipine group were still higher than in the sham-operated group. The I/R damage was ameliorated by amlodipine pretreatment, as evidenced by histopathological analysis. Conclusion: The present study is the fi rst to report an attenuation of I/Rinduced intestinal injury by the systemic administration of amlodipine. [ABSTRACT FROM AUTHOR]