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Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signalling....

Authors :
Dong Yan
Wiesmann, Marion
Rohan, Michael
Chan, Vivien
Jefferson, Ann B.
Lida Guo
Sakamoto, Doreen
Caothien, Roger H.
Fuller, John H.
Reinhard, Christoph
Garcia, Pablo D.
Randazzo, Filippo M.
Escobedo, Jaime
Fantl, Wendy J.
Williams, Lewis T.
Source :
Proceedings of the National Academy of Sciences of the United States of America. 12/18/2001, Vol. 98 Issue 26, p14973. 6p. 2 Diagrams, 5 Graphs.
Publication Year :
2001

Abstract

Determines the activation of Wnt/beta-catenin pathway in human colon cancers. Effect of beta-catenin antisense oligodeoxynucleotides on the level of axin2 and human naked cuticle (hnkd) mRNA; Expression of axin2 and hnkd in colon cancer cell lines; Correlation of the increased expression of axin2 and hnkd with truncations in polyposis coli.

Details

Language :
English
ISSN :
00278424
Volume :
98
Issue :
26
Database :
Academic Search Index
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
5932606
Full Text :
https://doi.org/10.1073/pnas.261574498