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Engineered Disulfide Linking the Hinge Regions within Lactose Repressor Dimer Increases Operator....

Authors :
Falcon, Catherine M.
Matthews, Kathleen S.
Source :
Biochemistry. 12/25/2001, Vol. 40 Issue 51, p15650. 10p. 2 Color Photographs, 1 Diagram, 1 Chart, 8 Graphs.
Publication Year :
2001

Abstract

Examines the role of hinge region of lactose repressor in DNA binding affinity, sequence selectivity and allosteric response. Function of hinge region of lactose repressor; Introduction of disulfide bond; Alteration of half-site spacing.

Subjects

Subjects :
*LACTOSE
*DNA

Details

Language :
English
ISSN :
00062960
Volume :
40
Issue :
51
Database :
Academic Search Index
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
5924766
Full Text :
https://doi.org/10.1021/bi0114067